Maria Bondesson, Associate Professor
Department of Intelligent Systems Engineering
Indiana University Bloomington
Zebrafish in Toxicity Screening
We use zebrafish as a research model to study effects of toxic exposures. The zebrafish model has several advantages for toxicity screening; breeding pairs produce hundreds of embryos, the embryos are small and develop fast, they are transparent and easy to maintain. These features allow for automation of toxicity testing, where thousands of chemicals can be screened.
We use transgenic fish with tissue specific fluorescence to screen for compounds that perturb vascular, skeletal and neuromast development.
We also use zebrafish embryos to indentify endocrine disrupting compounds, which are compounds that interfere with normal hormone signaling.